Chemistry 630 650: Metal-mediated synthetic transformations and mechanisms

This course will address certain mechanistic and synthetic applications of a variety of metal-mediated reactions. We will cover both stoichiometric and catalytic reactions that apply both transition metals and main group metals to inorganic and organic synthetic problems. We will use both quantitative and qualitative descriptions of the reactions and will cover applications, experimental methods and theory. 

Heavy atom and group transfer reactions

Catalytic, asymmetric hydrogenation reactions

Oxidation by high valent transition metals

Asymmetric hydroxylations and epoxidations

Hydroformylation

Hydrocarbyl transfer

Cross-coupling and other metathetical reactions

Electron transfer reactions

Outer sphere reactions

Inner sphere reactions

Electron transfers in proteins

Inorganic reaction mechanisms

Inert and labile systems

Charge transfer and hydrogen atom transfers

Ligand exchange, reorganization and elimination reactions

Experimental methods

NMR

Time-resolved methods

Synthetic methods

Polymerization and cyclization reactions

Ziegler-Natta polymerization

Brookhart-Gibson polymerization

Small molecule activation

O-atom transfer

N-atom transfer

Bond insertion processes

Transition metal and heteroatom transformations

Course requirements

It is assumed that you are fully conversant with chemical applications of group theory to structure and bonding problems and that you have a working knowledge of chemical kinetics. It is also assumed that you can write credible organic mechanisms that can explain and predict stereochemistry, product distributions and product structures. A working knowledge of the descriptive chemistry of the transition and main group metals will also be useful.

Selected Literature




Assignments


Notes and materials




Contact details

Dr. J. F. C. Turner       409 Buehler (office )     406-408 Buehler (lab)       Turner Group Home Page



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