Home
10 20 30
Human MNIKGSPWKGSLLLLL***V SNLLLCQSVAP
Chimpanzee MNIKGSPWKGSLLLLL***V SNLLLCHSVAP
Rhesus monkey MNIKGSPWKGSLLLLL***V SNLLLCQNVAP
Marmoset SLLLLL***V SNLLLWQSVTP
SlowLoris SLLLLLLILL SNLLLCKSVAS
Ox MDSKGSSQKGSRLLLLLV*V SNLLLCQGVVS
Sheep MDSKGSAQKGSRLLLLLV*V SNLLLCQGVVS
Goat MDSKGSAQKGSRLLLLLV*V SNLLLCQGVVS
Pig MDNTGSSQKGSLLLLLLL*V GNLFLCKSVAS
Cat MDNKGWSLKGSLLFLLLLLL SDLLLCKSVAS
Rabbit MDSKWSRRTGSLLLLL***V SNLLLCKSTAS
Rat MNSQVSARKAGTLLLLM**M SNLLFCQNVQT
Mouse MNSQGSAQKAGTLLLLL**I SNLLFCQNVQP
Hamster MNSQGSDRKAVTLLLLV**M SNLLFCQNAHP
Ancestral p.m. MDSKGSSRKGSLLLLLL**V SNLLLCKSVAS
Possum MGTKRSSLKGSLLLLLL**M SSLFLFKSVES
Monodelphis MCPKGSSVKGSLLLLLL**M SSRFLFKAVES
A sequence was predicted for the prolactin signal peptide of the ancestral placental mammal (Anc.p.m.) by making the simplifying assumption that all eutherian mammalian orders diverged at the same point in evolutionary time. The following alignment shows differences between extant sequences and this ancestral one (- indicates identity, * indicates gap):
Diff from a.p.m.
Human -NI---PW--------***- ------Q---P 6 & indel
Chimpanzee -NI---PW--------***- ------H---P 6 & indel
Rhesus monkey -NI---PW--------***- ------QN--P 7 & indel
Marmoset ------***- -----WQ--TP
SlowLoris -------ILL -----------
Ox -------Q---R-----V*- ------QG-V- 5 & indel
Sheep ------AQ---R-----V*- ------QG-V- 6 & indel
Goat ------AQ---R-----V*- ------QG-V- 6 & indel
Pig --NT---Q---------L*- G--F------- 5 & indel
Cat --N--W-L-----F---LLL -D--------- 6 & indel
Rabbit ----W-R-T-------***- --------T-- 4 & indel
Rat -N-QV-A--AGT----M**M ----F-QN-QT 14
Mouse -N-Q--AQ-AGT-----**I ----F-QN-QP 13
Hamster -N-Q--D--AVT----V**M ----F-QNAHP 15
Ancestral.p.m. MDSKGSSRKGSLLLLLL**V SNLLLCKSVAS
Possum -GT-R--L---------**M -S-F-F---E-
Monodelphis -CP----V---------**M -SRF-F-A-E-
Back to list of Prolactin Alignments