Literature: A-K ; L-Z ; subject area
Compiled by: Julian Thorpe
cyclic AMP-dependent protein kinase (PKA)
|
Please Note: Due to time constraints, the text part of this page has not been updated for some time. However, references are added reasonably frequently. |
PKA:
 | In regard to Pin1, phosphorylation of its WW domain (at Ser16)
by PKA abolishes the interactions between Pin1 and its target proteins (Lu
et al., 2002). It was also demonstrated that Pin1 is
dephosphorylated in a cell cycle-regulated manner, with the appearance of a
faster-migrating band at mitosis. |
| With regard to kinase inhibitors, Borgne and Meijer (1999)
anticipate the discovery of novel selective and powerful (kinase) inhibitors
which may be of therapeutic value in AD. |
| Nakamura et al. (2000) demonstrated that bovine (
neurofilament
) NF-L was phosphorylated by PKA at Ser41, Ser55, and Ser62 in the head
region. They also showed that Ser55 phosphorylation could be modulated by
okadaic acid-sensitive phosphatases. |
| 14-3-3 is a highly conserved protein family that exists as seven isoforms and regulates diverse cellular processes. It is present in NFTs (Layfield et al., 1996). Hashiguchi et al (2000) found that 14-3-3 (zeta isoform) was associated with tau in brain extract and profoundly stimulated cAMP-dependent protein kinase catalyzed in vitro phosphorylation on Ser(262)/Ser(356) located within the microtubule -binding region of tau. They suggested that 14-3-3(zeta) is a tau protein effector involved in abnormal tau phosphorylation |
Ahlijanian MK; Barrezueta NX; Williams RD; Jakowski A; Kowsz KP; McCarthy S; Coskran T; Carlo A; Seymour PA; Burkhardt JE;Nelson RB; McNeish JD (2000). Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97: 2910-2915
Andorfer, CA and Davies, P (2000) PKA phosphorylations on tau: Developmental studies in the mouse. DEVELOPMENTAL NEUROSCIENCE 22: 303-309
Borgne, A and Meijer, L (2000) The search for and potential therapeutic applications of chemical inhibitors of cyclin-dependent kinases. M S-MEDECINE SCIENCES 15: 496-503
Brownlees J, Yates A, Bajaj NP, Davis D, Anderton BH, Leigh PN, Shaw CE, Miller CC (2000) Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3. J Cell Sci 113: 401-7
BUSH_ML, MIYASHIRO_JS, INGRAM_VM. (1995) ACTIVATION OF A NEUROFILAMENT KINASE, A TAU KINASE, AND A TAU PHOSPHATASE BY DECREASED ATP LEVELS IN NERVE GROWTH FACTOR-DIFFERENTIATED PC-12 CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, Vol.92, No.6, pp.1861-1865
Cobb, M.H., Hepler, J.E., Zhen, E., Ebert, D., Cheng, M., Dang, A. and Robbins, D. (1995) Regulation and Structure of the MAP Kinases ERK1 and ERK2. pp. 78-87 In: Alzheimer's Disease: Lessons from Cell Biology. Eds. K.S. Kosik, Y. Christen and D.J. Selkoe. Springer-Verlag.
Crenshaw DG, Yang J, Means AR, Kornbluth S (1998) The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J 17:1315-1327
Delobel, P, Flament, S, Hamdane, M, Delacourte, A, Vilain, JP, Buee,
L (2002) Modelling Alzheimer-specific abnormal Tau phosphorylation
independently of GSK3 beta and PKA kinase activities. FEBS LETTERS 516:
151-155
Giasson_BI, Mushynski_WE. (1997) Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit. JOURNAL OF NEUROSCIENCE, 1997, Vol.17, No.24, pp.9466-9472
Gong C-X, Lidsky T, Weigel J, Zuck L, Grundke-Iqbal, I, Iqbal K (2000) Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. J Biol Chem 275: 5535-5544
Hashiguchi, M, Sobue, K and Paudel, HK (2000) 14-3-3 zeta is an effector of tau protein phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 275: 25247-25254
HOSOI_T, UCHIYAMA_M, OKUMURA_E, SAITO_T, ISHIGURO_K, UCHIDA_T, OKUYAMA_A, KISHIMOTO_T, HISANAGA_S. (1995) EVIDENCE FOR CDK5 AS A MAJOR ACTIVITY PHOSPHORYLATING TAU-PROTEIN IN PORCINE BRAIN EXTRACT. JOURNAL OF BIOCHEMISTRY, 1995, Vol.117, No.4, pp.741-749
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James_ND, Davis_DR, Sindon_J, Hanger_DP, Brion_JP, Miller_CCJ, Rosenberg_MP, Anderton_BH, Propst_F. (1996) Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine threonine kinase Mos. NEUROBIOLOGY OF AGING, 1996, Vol.17, No.2, pp.235-241
Julien JP; Mushynski WE. (1998) Neurofilaments in health and disease.Prog Nucleic Acid Res Mol Biol, 1998, 61:, 1-23
Kosik KS, Ferreira A, Knowles R, Leclerc N and Greenberg SM (1995) Linking amyloid precursor protein processing and tau-related pathology in Alzheimer's disease. pp. 230-240 In: Alzheimer's Disease: Lessons from Cell Biology. Eds. K.S. Kosik, Y. Christen and D.J. Selkoe. Springer-Verlag.
Layfield, R., Fergusson, J., Aitken, k, Lowe, J., Landon, NI. and Mayer, R. J. (1996) Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins. Neurosci. Lett. 209: 57-60
LEW_J, WANG_JH. (1995) NEURONAL CDC2-LIKE KINASE. TRENDS IN BIOCHEMICAL SCIENCES, 1995, Vol.20, No.1, pp.33-37
LEW_J, QI_Z, HUANG_QQ, PAUDEL_H, MATSUURA_I, MATSUSHITA_M, ZHU_XJ, WANG_JH. (1995) STRUCTURE, FUNCTION, AND REGULATION OF NEURONAL CDC2-LIKE PROTEIN-KINASE. NEUROBIOLOGY OF AGING, 1995, Vol.16, No.3, pp.263-268
Lichtenberg-Kraag B, Mandelkow EM, Biernat J, Steiner B, Schroter C, Gustke N, Meyer HE, Mandelkow E. (1992) Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proc Natl Acad Sci U S A, 1992 Jun, 89:12, 5384-8
Liu, F, Zaidi, T, Iqbal, K, Grundke-Iqbal, I, Gong, CX
(2002) Aberrant glycosylation modulates phosphorylation of tau
by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5
Lu, PJ, Zhou, XZ, Liou, YC, Noel, JP, Lu, KP (2002) Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. JOURNAL OF BIOLOGICAL CHEMISTRY 277: 2381-2384
Mandelkow, E-M, Biernat, J., Lichtenberg-Kraag, B., Drewes, G., Wille, H., Gustke, N., Baumann, K. and Mandelkow, E. (1995) Phosphorylation of tau and its relationship with Alzheimer paired helical filaments. pp. 103-120 In: Alzheimer's Disease: Lessons from Cell Biology. Eds. K.S. Kosik, Y. Christen and D.J. Selkoe. Springer-Verlag.
Nakamura Y; Hashimoto R; Kashiwagi Y; Aimoto S; Fukusho E; Matsumoto N; Kudo T; Takeda M (2000) Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture. J Neurochem 74: 949-59
Perry_G, Roder_H, Nunomura_A, Takeda_A, Friedlich_AL, Zhu_XW, Raina_AK, Holbrook_N, Siedlak_SL, Harris_PLR, Smith_MA. (1999) Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. NEUROREPORT, 1999, Vol.10, No.11, pp.2411-2415
QI_Z, TANG_DM, MATSUURA_I, LEE_KY, ZHU_XJ, HUANG_QQ, WANG_JH. (1995) REGULATORY PROPERTIES OF NEURONAL CDC2-LIKE KINASE. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1995, Vol.149, pp.35-39
Roder, H.M., Eden, P.A. and Ingram, V.M. (1993) Brain protein kinase pk40(erk) converts tau into a PHF-like form as found in Alzheimer's disease. Biochem. Biophys. Res. Comm. 193: 639-647
RODER_HM, HOFFMAN_FJ, SCHRODER_W. (1995) PHOSPHATASE RESISTANCE OF ERK2 BRAIN KINASE PK40(ERK2). JOURNAL OF NEUROCHEMISTRY, 1995, Vol.64, No.5, pp.2203-2212
Tokuoka H; Saito T; Yorifuji H; Wei F; Kishimoto T; Hisanaga S (2000) Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons. J Cell Sci 113: 1059-68
Trojanowski, J.Q., Mawal-Dewan, M., Scmidt, M.L., Martin, J. and Lee, VM-Y. (1993) Localisation of the mitogen activated protein kinase ERK2 in Alzheimer's Disease neurofibrillary tangles and senile plaque neurites. Brain Research 618: 333-337
Veeranna, Amin_ND, Ahn_NG, Jaffe_H, Winters_CA, Grant_P, Pant_HC. (1998) Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. JOURNAL OF NEUROSCIENCE, 1998, Vol.18, No.11, pp.4008-4021
VEERANNA, SHETTY_KT, LINK_WT, JAFFE_H, WANG_J, PANT_HC. (1995) NEURONAL CYCLIN-DEPENDENT KINASE-5 PHOSPHORYLATION SITES IN NEUROFILAMENT PROTEIN (NF-H) ARE DEPHOSPHORYLATED BY PROTEIN PHOSPHATASE 2A. JOURNAL OF NEUROCHEMISTRY, 1995, Vol.64, No.6, pp.2681-2690
Veeranna GJ; Shetty KT; Takahashi M; Grant P; Pant HC (2000) Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain. Brain Res Mol Brain Res, 2000 76: 229-36
Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter A (1999) The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G2/M progression. J Cell Science 112: 3361-3371