Alzheimer's Disease and Frontotemporal Dementias

A Review with Particular Reference to Pin1 Protein

 

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Compiled by: Julian Thorpe

 

Possible Pin1 Interactions in AD


N.B. This diagram is very much a preliminary affair and is under construction at present
Also, please see other diagrams of: Pin1 and tangles ; Pin1 and plaques : Pin1 and apoptosis in AD

Diagram of Possible Pin1 Interaction Events in AD   References

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References

(1) Bregman, DB, Pestell, RG and Kidd, VJ (2000) Cell cycle regulation and RNA polymerase II . FRONTIERS IN BIOSCIENCE 5: D244-D257

(2) Cataldo, AM, Peterhoff, CM, Troncosco, JC, Gomez-Isla, T, Hyman, BT and Nixon, RA (2000) Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome - Differential effects of APOE genotype and presenilin mutations. AMERICAN JOURNAL OF PATHOLOGY 157: 277-286

(3) Ding, XL, Husseman, J, Tomashevski, A, Nochlin, D, Jin, LW and Vincent, I (2000) The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. AMERICAN JOURNAL OF PATHOLOGY 157: 1983-1990

(4) Harris, PLR, Zhu, XW, Pamies, C, Rottkamp, CA, Ghanbari, HA, McShea, A, Feng, Y, Ferris, DK and Smith, MA (2000) Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes. NEUROBIOLOGY OF AGING 21: 837-841

(5) Zhou, XZ, Kops, O, Werner, A, Lu, PJ, Shen, MH, Stoller, G, Kullertz, G, Stark, M, Fischer, G and Lu, KP (2000) Pin1 -dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau protein. MOLECULAR CELL 6: 873-883

(6) Wu, Q, Combs, C, Cannady, SB, Geldmacher, DS and Herrup, K (2000) Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons. NEUROBIOLOGY OF AGING 21: 797-806

(7) Davies P, DeBernardis J, Espinoza M, Stahl, M, Vianna C (2000) APP and tau phosphorylation in Alzheimer's disease. World Alzheimer Congress 2000; abstract 956. Brain Pathol  10: 493

(8) Feng Y, Hodge DR, Palmieri G, Chase DL, Longo DL, Ferris DK (1999) Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex. Biochemical Journal 339:  435-442

(9) Gerez L, Mohrmann K, van Raak M, Jongeneelen M, Zhou XZ, Lu KP and van der Sluijs P (2000) Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase Pin1 during mitosis. Molecular Biology of the Cell 11: 2201-2211

(10) Crenshaw DG, Yang J, Means AR, Kornbluth S (1998) The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J 17:1315-1327

(11) Albert_A, Lavoie_S, Vincent_M (1999) A hyperphosphorylated form of RNA polymerase II is the major interphase antigen of the phosphoprotein antibody MPM-2 and interacts with the peptidyl-prolyl isomerase Pin. JOURNAL OF CELL SCIENCE 112: 2493-2500

(12) Lu_PJ, Wulf_G, Zhou_XZ, Davies_P, Lu_KP (1999) The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. NATURE 399: 784-788

(13) Pathan, N, Aime-Sempe, C, Kitada, S, Haldar, S and Reed, JC (2001) Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. Neoplasia 3: 70-79

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