Alzheimer's Disease and Frontotemporal Dementias

A Review with Particular Reference to Pin1 Protein

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Compiled by: Julian Thorpe

Alzheimer's Disease (AD) Neurofibrillary Tangles: TEM Images

See Tau Pathology from Frontotemporal Dementias

From: Thorpe, J.R., Morley, S.J. and Rulten, S.L . (2001) Utilising the Peptidyl-Prolyl Cis-Trans Isomerase Pin1 as a Probe of its Phosphorylated Target Proteins: Examples of Binding to Nuclear Proteins in a Human Kidney Cell Line and to Tau in Alzheimer’s Diseased Brain. J. Histochem. Cytochem. 49: 97-108

Digital TEM Images (left) showing an example of a neuron in AD brain tissue containing a neurofibrillary tangle (marked by *) (right) an enlarged view of a portion of the tangle area (*)
(sections immunogold-labelled for tau protein)