Literature: A-K ; L-Z ; subject area
Compiled by: Julian Thorpe
Spurious Upregulation of Cell Cycle Events
|
Please Note: Due to time constraints, the text part of this page has not been updated for some time. However, references are added reasonably frequently. |
 | There is much recent research interest in increased
expression of cell cycle-related proteins in AD (e.g. see
Husseman et al., 2000; Vincent et al., 1996 and many other references
). |
| Although neurons of the adult brain are normally
considered to be in a ‘terminally-differentiated’ state ,
accumulation of mitotic phosphoepitopes - via the spurious re-expression
and activation of Cdc2/cyclin B (the mitotic phase regulating kinase)
and associated cell cycle-related proteins - has been shown in AD and has
attracted much research interest (Arendt et al., 1998 & 2000
; Busser et al., 1998 ; Cataldo et al., 2000; Ding
et al., 2000 ; Dranovsky et al., 2001; Giovanni et al.,
1999; Harris et al., 2000 ; Husseman et al., 2000;
Husseman et al., 2001; Illenberger et al., 1998; Nagy et al.,
2000; Vincent et al., 1996). It has been described as an ‘interrupted’
mitotic process which leads to associated cytoskeletal abnormalities (including
tangle
formation) and, ultimately, apoptosis (Anderson et al., 2000
; Engidawork et al., 2001; Mattson, 2000). |
| The cellular signal transduction pathways initiating
these cell-cycle events are triggered by the various deleterious
effects of AD upon the neurons, which might, for example, include beta-amyloid
protein-induced microglia (Wu et al., 2000). |
| Recently, data from a Drosophila tauopathy
model suggests that tau phosphorylation is upstream of cell cycle activation
(Khurana et al., 2006). This would lend more
support to our hypothesis that shorfalls of endogenous Pin1 would be
deleterious to neuronal function, rather than the opposing view that Pin1
might instigate neurodegeneration via cyclin D1 (and thence cell cycle)
activation. |
| Pin1's involvement in the upregulation
of cell cycle events |
Some Related References
:
http://www.freemedicaljournals.com/
(These journals include: Neurology,
Neurobiology of Disease, Journal of Neurochemistry, Alzheimer's
Disease Review)
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