N.B. Beta-amyloid   is covered in great detail in David Small's Alzheimer Web Page , where you can also subscribe to the amyloid mailing list and get a chance to read/exchange views with your fellow researchers. There is also a positive wealth of information at the Alzheimer Research Forum site, including some very entertaining and informative on-line discussions about key aspects of the disease.

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Some Related References 

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Abramova, NA, Cassarino, DS, Khan, SM, Painter, TW, Bennett, JP (2002) Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma. JOURNAL OF NEUROSCIENCE RESEARCH 67: 494-500

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Alvarez, G, Munoz-Montano, JR, Satrustegui, J, Avila, J, Bogonez, E, Diaz-Nido, J (2002) Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease. BIPOLAR DISORDERS 4: 153-165

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Buchet, R and Pikula, S (2000) Alzheimer's disease: Its origin at the membrane, evidence and questions. ACTA BIOCHIMICA POLONICA 47: 725-733

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Casanova, MF, Hill, WD, Pourdihimi, B (2001) Senile plaques exert no mass lesion effect on surrounding neurons. JOURNAL OF NEUROSCIENCE METHODS 110: 125-133

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Chen, FS, Yang, DS, Petanceska, S, Yang, A, Tandon, A, Yu, G, Rozmahel, R, Ghiso, J, Nishimura, M, Zhang, DM, Kawara, T, Levesque, G, Mills, J, Levesque, L, Song, YQ,  Rogaeva, E, Westaway, D, Mount, H, Gandy, S, St George-Hyslop, P and Fraser, PE (2000) Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. JOURNAL OF BIOLOGICAL CHEMISTRY 275: 36794-36802

Chen, M and Fernandez, HL (2001) Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency. FRONTIERS IN BIOSCIENCE 6: E1-E11

Chen, YZ (2004) APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin. APOPTOSIS 9: 415-422

Chen, YZ, Liu, WY, McPhie, DL, Hassinger, L, Neve, RL (2003) APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. JOURNAL OF CELL BIOLOGY 163: 27-33

Chishti, MA, Yang, DS, Janus, C, Phinney, AL, Horne, P, Pearson, J, Strome, R, Zuker, N, Loukides, J, French, J, Turner, S, Lozza, G, Grilli, M, Kunicki, S,, Morissette, C, Paquette, J, Gervais, F, Bergeron, C, Fraser, PE, Carlson, GA, St George-Hyslop, P and Westaway, D (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. JOURNAL OF BIOLOGICAL CHEMISTRY 276: 21562-21570

Cho, HS, Hyman, BT, Greenberg, SM and Rebeck, GW (2001) Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in A beta aggregation. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 60: 342-349

Choi, YT, Jung, CH, Lee, SR, Bae, JH, Baek, WK, Suh, MH, Park, J, Park, CW, Suh, SI (2002) The green tea polyphenol (-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons. LIFE SCIENCES 70: 603-614

Christie, RH, Bacskai, BJ, Zipfel, WR, Williams, RM, Kajdasz, ST, Webb, WW and Hyman, BT (2001) Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. JOURNAL OF NEUROSCIENCE 21: 858-864

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Chung, HM, Struhl, G (2001) Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. NATURE CELL BIOLOGY 3: 1129-1132

Chung, HY, Brazil, MI, Irizarry, MC, Hyman, BT and Maxfield, FR (2001) Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice. NEUROREPORT 12:1151-1154

Chyung, JH, Selkoe, DJ (2003) Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. JOURNAL OF BIOLOGICAL CHEMISTRY 278: 51035-51043

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Copani, A, Melchiorri, D, Caricasole, A, Martini, F, Sale, P, Carnevale, R, Gradini, R, Sortino, MA, Lenti, L, De Maria, R, Nicoletti, F (2002) beta-amyloid-induced synthesis of the ganglioside Gd3 is a requisite for cell cycle reactivation and apoptosis in neurons. JOURNAL OF NEUROSCIENCE 22: 3963-3968

Coraci, IS, Husemann, J, Berman, JW, Hulette, C, Dufour, JH, Campanella, GK, Luster, AD, Silverstein, SC, El Khoury, JB (2002) CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. AMERICAN JOURNAL OF PATHOLOGY 160: 101-112

Corder, EH, Woodbury, MA, Volkmann, I, Madsen, DK, Bogdanovic, N and Winblad, B (2000) Density profiles of Alzheimer disease regional brain pathology for the Huddinge brain bank: pattern recognition emulates and expands upon Braak staging. EXPERIMENTAL GERONTOLOGY 35: 951-864

Cottingham, MG, Hollinshead, MS. Vaux, DJT (2002) Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide . BIOCHEMISTRY 41: 13539-13547

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Creemers, JWM, Dominguez, DI, Plets, E, Serneels, L, Taylor, NA, Multhaup, G, Craessaerts, K, Annaert, W and De Strooper, D (2001) Processing of beta-secretase by furin and other members of the proprotein convertase family. JOURNAL OF BIOLOGICAL CHEMISTRY 276: 4211-4217

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D'Andrea, MR, Nagele, RG, Gumula, NA, Reiser, PA, Polkovitch, DA, Hertzog, BM, Andrade-Gordon, P (2002) Lipofuscin and A beta 42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains. NEUROSCIENCE LETTERS 323: 45-49

D'Andrea, MR, Nagele, RG, Wang, HY, Peterson, PA and Lee, DHS (2001) Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. HISTOPATHOLOGY 38:120-134

D'Andrea, MR, Nagele, RG, Wang, HY, Lee, DHS (2002) Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex . NEUROSCIENCE LETTERS 333: 163-166

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Das, P, Murphy, MP, Younkin, LH, Younkin, SG, Golde, TE (2001) Reduced effectiveness of A beta 1-42 immunization in APP transgenic mice with significant amyloid deposition. NEUROBIOLOGY OF AGING 22: 721-727

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Davies, P, DeBernardis, J, Espinoza, M, Stahl, M and Vianna, C (2000) APP and tau phosphorylation in Alzheimer's disease. BRAIN PATHOLOGY 10: 493

DAVIS_DR, BRION_JP, COUCK_AM, GALLO_JM, HANGER_DP, LADHANI_K, LEWIS_C, MILLER_CCJ, RUPNIAK_T, SMITH_C, ANDERTON_BH. (1995) THE PHOSPHORYLATION STATE OF THE MICROTUBULE-ASSOCIATED PROTEIN TAU AS AFFECTED BY GLUTAMATE, COLCHICINE AND BETA-AMYLOID IN PRIMARY RAT CORTICAL NEURONAL CULTURES. BIOCHEMICAL JOURNAL, 1995, Vol.309, No.Pt3, pp.941-949

Deb, S, Zhang, JW, Gottschall, PE (2003) beta-amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes. BRAIN RESEARCH 970: 205-213

De Ceballos, ML, Brera, B and Fernandez-Tome, MP (2001) beta-Amyloid-induced cytotoxicity, peroxide generation and blockade of glutamate uptake in cultured astrocytes. CLINICAL CHEMISTRY AND LABORATORY MEDICINE 39: 317-318

De Ferrari, GV, Chacon, MA, Barria, MI, Garrido, JL, Godoy, JA, Olivares, G, Reyes, AE, Alvarez, A, Bronfman, M, Inestrosa, NC (2003) Activation of Wnt signaling and behavioral impairments rescues neurodegeneration induced by beta-amyloid fibrils. MOLECULAR PSYCHIATRY 8: 195-208

De Jonghe, C, Esselens, C, Kumar-Singh, S, Craessaerts, K, Serneels, S, Checler, F, Annaert, W, Van Broeckhoven, C and De Strooper, B (2001) Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability. HUMAN MOLECULAR GENETICS 10: 1665-1671

Delacourte, A, Sergeant, N, Champain, D, Wattez, A, Maurage, CA, Lebert, F, Pasquier, F, David, JP (2002) Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. NEUROLOGY 59: 398-407

DeMattos, RB, Bales, KR, Cummins, DJ, Dodart, JC, Paul, SM and Holtzman, DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98: 8850-8855

DeMattos, RB, Bales, KR, Cummins, DJ, Paul, SM, Holtzman, DM (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. SCIENCE 295: 2264-2267

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De Strooper, B, Annaert, W (2001) Presenilins and the intramembrane proteolysis of proteins: facts and fiction. NATURE CELL BIOLOGY 3: E221-E225

Dewachter, I, Reverse, D, Caluwaerts, N, Ris, L, Kuiperi, C, Van den Haute, C, Spittaels, K, Umans, L, Serneels, L, Thiry, E, Moechars, D, Mercken, M, Godaux, E, Van Leuven, F (2002) Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. JOURNAL OF NEUROSCIENCE 22: 3445-3453

Dewachter, I, Van Dorpe, J, Smeijers, L, Gilis, M, Kuiperi, C, Laenen, I, Caluwaerts, N, Moechars, D, Checler, DR, Vanderstichele, H and Van Leuven, F (2000) Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. JOURNAL OF NEUROSCIENCE 20: 6452-6458

Dewachter, I, van Dorpe, J, Spittaels, K, Tesseur, I, Van Den Haute, C, Moechars, D and Van Leuven, F (2000) Modeling Alzheimer's disease in transgenic mice: effect of age and of Presenilin1 on amyloid biochemistry and pathology in APP/London mice. EXPERIMENTAL GERONTOLOGY 35: 831-841

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