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Professor Adam Eyre-Walker

Royal Society University Research Fellow
Co-director of the CSE

+44 (0)1273 678 480

5B8 JMS Building



Complete publication list

Piganeau, G.V. & Eyre-Walker, A. (2003) Estimating the distribution
of fitness effects from DNA sequence data: implications for the
m olecular clock. Proc. Natl. Acad. Sci. USA 100, 10335-10340. PDF

Smith NGC, Eyre-Walker A (2003) Partitioning the variation in mammalian substitution rates. Molecular Biology and Evolution 20, 10-17. PDF

Eyre-Walker A (2002) Changing effective population size and the McDonald-Kreitman test. Genetics 162, 2017-2024. PDF

Lercher M.J., Smith,N.G.C., Eyre-Walker, A. & Hurst, L.D. (2002) The evolution of isochores: evidence from SNP frequency distributions. Genetics 162,1805-1810. PDF

Eyre-Walker A, Keightley PD, Smith NGC, Gaffney D (2002) Quantifying the slightly deleterious model of molecular evolution. Molecular Biology and Evolution 19, 2142-2149. PDF

Belle EMS, Eyre-Walker A (2002) Analysis of the phylogenetic distribution of isochores in vertebrates and a test of the thermal stability hypothesis. Journal of Molecular Evolution. 55: 356-363. PDF

Belle EMS, Eyre-Walker A (2002) A test of whether selection maintains isochores using sites polymorphic for Alu and L1 elements. Genetics 160: 815-817. PDF

Smith NGC, Eyre-Walker A (2002) Adaptive protein evolution in Drosophila. Nature 415: 1022-1024. PDF

Smith NGC, Eyre-Walker A (2002) The compositional evolution of the murid genome. Journal of Molecular Evolution 55: 197-201. PDF

Eyre-Walker A (2002) Codon Usage Bias. Encyclopedia of Evolution.

Eyre-Walker A, Hurst LD (2001) The evolution of isochores. Nature Reviews Genetics 2: 549-555.PDF

Eyre-Walker A, Awadalla P (2001) Does human mtDNA recombine? Journal of Molecular Evolution 53: 430-435. PDF

Keightley PD, Eyre-Walker A (2001) Response to Kondrashov : Sex and U. Trends in Genetics 17: 77-78. PDF

Eyre-Walker A (2001) Base composition patterns. Encyclopedia of Life Sciences.

Meunier J, Eyre-Walker A (2001) The Correlation between Linkage Disequilibrium and Distance. Implications for Recombination in Hominid Mitochondria. Molecular Biology and Evolution 18: 2127-2131. PDF

Smith NGC, Eyre-Walker A (2001) Nucleotide Substitution Rate Estimation in Enterobacteria: Approximate and Maximum-Likelihood Methods Lead to Similar Conclusions Molecular Biology and Evolution 18: 2124-2126 PDF

Smith NGC, Eyre-Walker A (2001) Why are translationally sub-optimal synonymous codons used in Escherichia coli? Journal of Molecular Evolution 53: 225-236 PDF

Smith NGC, Eyre-Walker A. (2001) A test of amino acid reversibility. Journal of Molecular Evolution 52: 467-469 PDF

Smith NGC, Eyre-Walker A (2001) Synonymous codon bias is not caused by mutation bias in G+C rich genes in humans. Molecular Biology and Evolution 18: 982-986 PDF

Keightley PD, Eyre-Walker A (2000) Deleterious mutations and the evolution of sex. Science 290: 331-333 PDF

Eyre-Walker A (2000) Do mitochondria recombine in humans? Philosophical Transactions of the Royal Society Series B. 355: 1573-1580 PDF

Awadalla P, Eyre-Walker A, Maynard Smith J (2000) Questioning evidence for recombination in human mitochondrial DNA. Science 288: 1931a PDF

Hurst LD, Eyre-Walker A (2000) Reading the bands. Bioessays 22: 105-107

Eyre-Walker A, Smith NH, Maynard Smith J (1999) Reply to Macaulay et al. (1999): mtDNA recombination – reasons to panic. Proceedings of the Royal Society Series B. 266: 2041-2042 PDF

Keightley PD, Eyre-Walker A (1999) Terumi Mukai and the riddle of deleterious mutation rates. Genetics 153: 515-523 PDF

Awadalla P, Eyre-Walker A, Maynard Smith J (1999) Linkage disequilibrium and recombination in hominid mitochondrial DNA. Science 286: 2524-2525 PDF

Eyre-Walker A (1999) Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA. Genetics 152: 675-683 PDF

Eyre-Walker A, Keightley PD (1999) High genomic deleterious mutation rates in hominids. Nature 397: 344-347 PDF

Eyre-Walker A, Smith NH, Maynard Smith J (1999) How clonal are human mitochondria? Proceedings of the Royal Society Series B. 266: 477-483 PDF

Eyre-Walker A (1998) Problems with parsimony in sequences of biased base composition. Journal of Molecular Evolution 47: 686-690 PDF

Kliman RM, Eyre-Walker A (1998) Patterns of base composition within Drosophila genes. Journal of Molecular Evolution 46:534-541 PDF

Eyre-Walker A, Gaut RL, Hilton H, Feldman DL, Gaut BG (1998) Investigation of the bottleneck leading to the domestication of maize, using the coalescent. Proceedings of the National Academy of Sciences USA 95: 4441-4446 PDF

Akashi H, Eyre-Walker A (1998) Translational selection and molecular evolution. Current Opinions in Genetic Development Bioliogy 8: 688-693

Akashi H, Kliman RM, Eyre-Walker A (1998) Mutation pressure, natural selection and the evolution of base composition in Drosophila. Genetica 103: 49-60

Peck JR, Eyre-Walker A (1997) The Muddle about mutations. Nature 387:135-136

Eyre-Walker A (1997) Differentiating between selection and mutation bias. Genetics 147: 1983-1987 PDF

Eyre-Walker A, Gaut BG (1997) Correlated rates of synonymous site evolution across plant genomes. Molecular Biology and Evolution 14: 455-460 PDF

Eyre-Walker A (1996) Synonymous codon bias is related to gene length in Escherichia coli: evidence of selection for translational accuracy? Molecular Biology and Evolution 13: 864-872 PDF

Eyre-Walker A (1996) The close proximity of Escherichia coli genes: implications for stop codon and synonymous codon use. Journal of Molecular Evolution 42: 73-78

Eyre-Walker A, Bulmer M (1995) Synonymous substitution rates in enterobacteria. Genetics 140: 1407-1412 PDF

Eyre-Walker A (1995) The distance between Escherichia coli genes is related to the level of gene expression. Journal of Bacteriology 177: 5368-5369

Eyre-Walker A (1995) Does very short patch (VSP) repair efficiency vary in relation to gene expression level? Journal of Molecular Evolution 40:705-706

Eyre-Walker A (1994). DNA mismatch repair and synonymous codon evolution in mammals. Molecular Biology and Evolution 11: 88-98 PDF

Eyre-Walker A (1994) Synonymous substitutions are clustered in enterobacterial genes. Journal of Molecular Evolution 39: 448-451

Eyre-Walker A (1993). Recombination and genome evolution in mammals. Proceedings of the Royal Society Series B. 252: 237-243

Eyre-Walker A, Bulmer M (1993) Reduced synonymous substitution rate at the start of enterobacterial genes. Nucleic Acids Research 21: 4599-4603

Eyre-Walker A (1992) The role of DNA replication and isochores in generating mutation and silent substitution rate variance in mammals. Genetical Research 60: 61-67

Eyre-Walker A (1992) Evidence that both G+C rich and G+C poor isochores replicate early and late in the cell cycle. Nucleic Acids Research 20: 1497-1501

Eyre-Walker A (1992) The effect of constraint on the rate of evolution in neutral models with biased mutation. Genetics 131: 233-234 PDF

Eyre-Walker A (1991) An analysis of codon usage in mammals: selection or mutation bias? Journal of Molecular Evolution 33: 442-449

Eyre-Walker A (1990) A recombination. Nature 345: 673





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